Membrane Bound Members of the M1 Family: More Than Aminopeptidases
- 1 October 2004
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Protein & Peptide Letters
- Vol. 11 (5) , 491-500
- https://doi.org/10.2174/0929866043406643
Abstract
Abstract: In mammals the M1 aminopeptidase family consists of nine different proteins, five of which are integral membrane proteins. The aminopeptidases are defined by two motifs in the catalytic domain; a zinc binding motif HEXXH-(X18)-E and an exopeptidase motif GXMEN. Aminopeptidases of this family are able to cleave a broad range of peptides down to only to a single peptide. This ability to either generate or degrade active peptide hormones is the focus of this review. In addition to their capacity to degrade a range of peptides a number of these aminopeptidases have novel functions that impact on cell signalling and will be discussed.Keywords
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