HLA Antigens in Schizophrenia: No Difference Between Patients with and Without Evidence of Brain Atrophy

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Abstract
Summary: The HLA antigens distribution was studied in 56 chronic schizophrenic in-patients with or without brain atrophy determined by CAT examination, and compared with that of 200 controls. There was no difference in the incidence of HLA-A2 in the whole sample, and an increase in those without brain atrophy (by comparison with normal controls) failed to reach statistical significance. A decrease of Bw35 in the whole sample, more prominent in those without brain atrophy, again failed to be significant after multiplying the probability by the number of antigens studied.