INFLUENCE OF FREQUENCY OF STIMULUS UPON RESPONSE TO HYPOTHALAMIC STIMULATION

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Abstract
The Horsley-Clarke stereotaxic apparatus was used for bipolar stimulation of the hypothalamus in 13 anesthetised cats. The stimulator, described in detail, delivered condenser discharges of the same wave form and voltage over a frequency range of 1-1600 per sec. Blood pressure and respiration were recorded; observations were made on pupillary and somatic responses. Frequency changes often affected the magnitude and sometimes altered the sign of the response. Low frequency stimulation (1-20 per sec.) usually caused a fall in blood pressure, constriction of the pupil, a slowing of respiration; high frequency (20-1600 per sec.) stimulation of the same area caused a rise in blood pressure, pupillary dilatation, an increase in rate and depth of respiration.

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