Modifications of Adenovirus Hexon Allow for Either Hepatocyte Detargeting or Targeting With Potential Evasion From Kupffer Cells

This publication has 37 references indexed in Scilit:

• Capsomer-Specific Fluorescent Labeling of Adenoviral Vector Particles Allows for Detailed Analysis of Intracellular Particle Trafficking and the Performance of Bioresponsive Bonds for Vector Capsid Modifications
  Human Gene Therapy, 2010
• An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood
  Gene Therapy, 2010
• Chemical Modification with High Molecular Weight Polyethylene Glycol Reduces Transduction of Hepatocytes and Increases Efficacy of Intravenously Delivered Oncolytic Adenovirus
  Human Gene Therapy, 2009
• Clearance of Adenovirus by Kupffer Cells Is Mediated by Scavenger Receptors, Natural Antibodies, and Complement
  Journal of Virology, 2008
• Substitution of Hexon Hypervariable Region 5 of Adenovirus Serotype 5 Abrogates Blood Factor Binding and Limits Gene Transfer to Liver
  Molecular Therapy, 2008
• Interaction of Systemically Delivered Adenovirus Vectors with Kupffer Cells in Mouse Liver
  Human Gene Therapy, 2008
• Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo
  Proceedings of the National Academy of Sciences, 2008
• Pseudo-hydrodynamic Delivery of Helper-dependent Adenoviral Vectors into Non-human Primates for Liver-directed Gene Therapy
  Molecular Therapy, 2007
• Improved Hepatic Transduction, Reduced Systemic Vector Dissemination, and Long-Term Transgene Expression by Delivering Helper-Dependent Adenoviral Vectors into the Surgically Isolated Liver of Nonhuman Primates
  Human Gene Therapy, 2006
• Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors
  Blood, 2003