Transmission of the Simian Immunodeficiency Virus SIVmne in Macaques and Baboons
- 1 June 1989
- journal article
- Published by Wiley in Journal of Medical Primatology
- Vol. 18 (3-4) , 237-245
- https://doi.org/10.1111/j.1600-0684.1989.tb00225.x
Abstract
A primate lymphotropic lentivirus was isolated on Hut 78 cells after cocultivation of a lymph node from a macaque that died with malignant lymphoma. In earlier studies SIV/Mne was inoculated into 17 macaques and two baboons. All of the macaques became viremic and seropositive. Fifteen of the macaques succumbed to a classic AIDS-like disease, whereas the baboons did not become viremic. The SIV/Mne virus has now been molecularly cloned and inoculated into Macaca nemestrina and baboons. A new transmission study has been initiated to test the effects of route and dosage on disease.Keywords
Funding Information
- National Institutes of Health (RR00166)
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