EXCRETION OF CATECHOLAMINES, 17-KETOSTEROIDS, 17-HYDROXYCORTICOIDS AND 5-HYDROXYINDOLE IN MEN EXHIBITING A PARTICULAR BEHAVIOR PATTERN (A) ASSOCIATED WITH HIGH INCIDENCE OF CLINICAL CORONARY ARTERY DISEASE*†

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Abstract
The urinary excretion of 17-ketosteroids, 17-hydroxycorticosteroids, 5-hydroxyindole, epinephrine and norepinephrine was measured in a group of 12 men exhibiting an overt behavior pattern (A) found in earlier studies to be associated with a high incidence of clinical coronary artery disease. The nocturnal urinary excretion of these hormones was found to be the same in these men as in control men exhibiting a converse behavior pattern. However, when urine formed during working hours was analyzed, it was found that a far greater increase in norepinephrine occurred in the urine of the men exhibiting Pattern A than in the control groups. The possible relevance of these findings to the pathogenesis of clinical coronary disease was discussed.