Effect of Vitamin D onin VitroBone Calcium Metabolism

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Abstract
The effects of vitamin D in vivo on the equilibrium of C and P between surviving bone and buffer have been examined in an in vitro system. Calvaria from rats pretreated with vitamin D in physiologic and in massive doses maintained significantly higher buffer C concentrations than those from vitamin D-deficient control rats. There were no consistent differences in buffer P. The calvaria from the vitamin D-treated rats released less lactate into the buffer than control calvaria. The effect of vitamin D was apparent in calvaria from parathyroidectomized rats, and also in calvaria from rats in which low serum C levels had been produced with a low-C diet. This study thus provides evidence for direct effects of vitamin D on bone metabolism.