Effects of streptozotocin-induced diabetes and noradrenaline infusion on cardiac output and its regional distribution in pithed rats

Publisher Website
Google Scholar
Abstract
Summary 46Sc-and 99mTc-labelled microspheres were used to measure the effects of noradrenaline infusion on cardiac output and its regional distribution in 10 control and 10 streptozotocin-diabetic pithed rats. Plasma noradrenaline concentrations during the infusion were similar in both groups. Pressor responses were significantly smaller in the diabetic animals (controls: + 79, diabetic: +44mmHg; ppppp<0.05), but were very similar in other areas, e.g. in the hindlimbs and tails.