II. Sensitivity and reliability of the discontinuous vacuum stability test

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Abstract
Gas evolution, due to phase expansion, remains an attractive and sensitive method for stability evaluation. Unfortunately, this technique is also sensitive to errors. Numerous factors such as pressure, volume, temperature, volatiles, and solubility, may significantly affect the results. The effect of such factors is evaluated. A better control of the test conditions prevents errors and makes the discontinuous VST a fast and accurate technique for stability/compatibility evaluation.

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