Testing of Antiviral Compounds against Mengo Virus Infection of Mice

Publisher Website
Google Scholar
Abstract
Lethal MengoM virus infection of mice was used as an in vivo test model to elucidate the prophylactic efficacy of 11 compounds which proved to be effective against the virus in vitro and, furthermore, to examine both the test system and the method of statistical evaluation used. Seven compounds were found to be significantly inhibitory against the virus as revealed by statistical evaluation on the basis of four criteria as ‘LT50’ (1), ‘difference of survival times’ (2), ‘rates of survivors’ (3), and ‘rate of protection’ (4). The criterion 4 is considered to be more efficient than the others because it revealed at least all the antiviral drugs which were discovered by 1, 2, and 3. Questions concerning the mechanisms of action, the differences of the activities, and the usefulness of the effective compounds as potential antiviral agents are discussed.

This publication has 0 references indexed in Scilit: