DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines
Open Access
- 25 January 2008
- journal article
- Published by Springer Nature in Molecular Cancer
- Vol. 7 (1) , 15
- https://doi.org/10.1186/1476-4598-7-15
Abstract
DNA hypermethylation events and other epimutations occur in many neoplasms, producing gene expression changes that contribute to neoplastic transformation, tumorigenesis, and tumor behavior. Some human cancers exhibit a hypermethylator phenotype, characterized by concurrent DNA methylation-dependent silencing of multiple genes. To determine if a hypermethylation defect occurs in breast cancer, the expression profile and promoter methylation status of methylation-sensitive genes were evaluated among breast cancer cell lines.Keywords
This publication has 62 references indexed in Scilit:
- DNA methylation-dependent silencing of CST6 in human breast cancer cell linesLaboratory Investigation, 2006
- Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer StudyJAMA, 2006
- Clinical Evaluation of E-cadherin Expression and its Regulation Mechanism in Epithelial Ovarian CancerClinical & Experimental Metastasis, 2006
- Phenotypic evaluation of the basal-like subtype of invasive breast carcinomaLaboratory Investigation, 2005
- DNA methylation and gene silencing in cancerNature Clinical Practice Oncology, 2005
- Promoter Hypermethylation Profile of Kidney CancerClinical Cancer Research, 2004
- A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancerNature Genetics, 2002
- Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsProceedings of the National Academy of Sciences, 2001
- Lipocalins and cancerBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2000
- The Hallmarks of CancerCell, 2000