Synchronization and integration of multiple hypertrophic pathways in the heart

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Abstract
Nine years ago, Cardiovascular Research (vol. 30(4), 1995) published a Spotlight Issue on signal transduction summarizing important cellular signaling events in cardiovascular cells. At that time, a main focus of research was centered on intracellular cascades modifying cellular responses in multiple cardiovascular cells, including vascular smooth muscle cells, cardiac fibroblasts, and cardiomyocytes. The present Spotlight Issue is intended to give the readership of Cardiovascular Research an update on the aforementioned signaling cascades involved in myocardial hypertrophy and to point out what has become increasingly evident during the last decade: multiple hypertrophic pathways work together in a complex scenario by integration and synchronization of a multitude of signals generated by distinct mechanisms. This editorial briefly introduces the topics covered in this Spotlight Issue.

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