Folgen des Gefäßkatheterismus am normo- und hypercholesterinaemischen Kaninchen

Publisher Website
Google Scholar
Abstract
The introduction of a ballon catheter through the femoral artery into the abdominal aorta of the rabbit causes primarily a partial endothelial destruction and occasional focal necrosis of smooth muscle cells. At stages of 4 wk. to 1 year after catheterization a lasting massive intimal hypertrophy is produced. Additional cholesterol feeding thickens the proliferating in- tima to such an extent that the vessel lumen?can be greatly constricted as a result of fatty infiltration. The interruption of blood flow in the aorta resulting from inflation of the balloon for 1 to 24 min. does not bring about any mural changes in those arteries of the pelvis and the leg which have not come into contact with the catheter. Measurement of the intimal thickness shows that severe mural damage induces a milder intimal hyperplasia than a moderate injury. In the later case (catheterization) the hypertrophic reaction of the vessel wall is excessive.