The Site Of The Activity Of Extracellular Products Of Pseudomonas Aeruginosa In The Electron-Transport Chain In Mammalian Cell Respiration

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Abstract
Since 1-hydroxyphenazine derived from Pseudomonas aeruginosa or chemically synthesised inhibited the uptake of oxygen by mouse liver mitochondria utilising sodium succinate, attempts were made to determine the site of activity in the electron transport chain. It was found that inhibition occurred at a site corresponding to ubiquinone (coenzyme Q) or Co Q-cytochrome b; the 1-hydroxyphenazine might act as an “ electron shunt” by accepting electrons and transporting them to a “ dead end ”.

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