Evidence That the Fosfomycin Target Cys115 in UDP-N-acetylglucosamine Enolpyruvyl Transferase (MurA) Is Essential for Product Release
Open Access
- 1 February 2005
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 280 (5) , 3757-3763
- https://doi.org/10.1074/jbc.m411325200
Abstract
No abstract availableKeywords
This publication has 39 references indexed in Scilit:
- Nonenzymatic Breakdown of the Tetrahedral (α-Carboxyketal Phosphate) Intermediates of MurA and AroA, Two Carboxyvinyl Transferases. Protonation of Different Functional Groups Controls the Rate and Fate of BreakdownJournal of the American Chemical Society, 2003
- In Vitro and In Vivo Functional Activity ofChlamydiaMurA, a UDP-N-Acetylglucosamine Enolpyruvyl Transferase Involved in Peptidoglycan Synthesis and Fosfomycin ResistanceJournal of Bacteriology, 2003
- The bacterial cell wall as a source of antibacterial targetsEmerging Therapeutic Targets, 2002
- Stereochemical Course of Enzymatic Enolpyruvyl Transfer and Catalytic Conformation of the Active Site Revealed by the Crystal Structure of the Fluorinated Analogue of the Reaction Tetrahedral Intermediate Bound to the Active Site of the C115A Mutant of MurABiochemistry, 1998
- [20] Processing of X-ray diffraction data collected in oscillation modePublished by Elsevier ,1997
- Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycinStructure, 1996
- The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesisChemistry & Biology, 1996
- Analysis of Fluoromethyl Group Chirality Establishes a Common Stereochemical Course for the Enolpyruvyl Transfers Catalyzed by EPSP Synthase and UDP-GlcNAc Enolpyruvyl TransferaseBiochemistry, 1996
- Evidence that the reaction of the UDP‐N‐acetylglucosamine 1‐carboxyvinyltransferase proceeds through the O‐phosphothioketal of pyruvic acid bound to Cys115 of the enzymeEuropean Journal of Biochemistry, 1993
- THE MECHANISM OF ACTION OF FOSFOMYCIN (PHOSPHONOMYCIN)Annals of the New York Academy of Sciences, 1974