A Convenient Synthesis of (±)-2-Carboxy-4-(3-phosphonopropyl)piperazine (CPP)
- 1 January 1992
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1992 (11) , 1065-1067
- https://doi.org/10.1055/s-1992-26301
Abstract
A short and convenient route to the N-methyl-D-aspartate (NMDA) antagonist 2-carboxy-4-(3-phosphonopropyl)piperazine (CPP), involving selective N-4 alkylation of piperazine-2-carboxylic acid esters, is described. The method uses readily available starting materials and is suitable for multigram quantities.Keywords
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