EVALUATION OF A NEW ANTI-INFLAMMATORY ANALGESIC COMPOUND F-776, 5-(4-CHLOROPHENYL)-BETA-HYDROXY-2-FURANPROPANOIC ACID

  • 1 January 1980
    • journal article
    • research article
    • Vol. 243  (2) , 331-350
Abstract
F-776, 5-(4-chlorophenyl)-.beta.-hydroxy-2-furanpropanoic acid, is a nonsteroidal anti-inflammatory, analgesic and antipyretic drug which does not produce stomach ulcers. It''s spectrum of activity includes full anti-inflammatory efficacy in bilaterally adrenalectomized rats; an ED50 value in the carrageenan hindpaw edema assay comparable to that of fenoprofen and ibuprofen; effectiveness in preventing and in diminishing developing and established adjuvant-induced polyarthritis in rats, respectively; significant reduction of granulation tissue formation around cotton pellets; significant decrease in erythema resulting from UV irradiation of guinea-pig skin; analgesia as determined in the rat paw pressure procedure; antipyretic activity in rats with yeast-induced fever and an uricosuric effect noted at higher than anti-inflammatory doses. F-776 is not an immunosuppressant as determined in the experimental allergic encephalomyelitis rat model. Its mechanism of action is undetermined. F-776 represents a new nonulcerogenic anti-inflammatory, analgesic and antipyretic compound with potential utility in different arthritic conditions.