THYMIC FUNCTION IN NZB MICE .2. REGULATORY INFLUENCE OF A CIRCULATING THYMIC FACTOR ON ANTIBODY-PRODUCTION AGAINST POLYVINYLPYRROLIDONE IN NZB MICE

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 117  (3) , 760-764
Abstract
Administration of a circulating thymic factor isolated from normal pig blood prevented the development of the exaggerated production of anti-polyvinyl pyrrolidone (PVP) antibody in young NZB mice. Treatment was ineffective if initiated after the 4th wk of life at a time when endogenous serum thymic factor (TF) normally disappears in these mice. Circulating TF is apparently necessary for the survival of short-lived suppressor T [thymus-derived] cells normally implicated in the regulation of the production of antibodies against PVP, a thymus-independent antigen. In older NZB mice, TF treatment increased anti-PVP antibody production, which suggests that amplifier T cell activity could also be under TF influence.

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