Oxidative Coupling of Arylboronic Acids with Arenes via Rh-Catalyzed Direct C−H Arylation
- 12 December 2007
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 10 (1) , 129-131
- https://doi.org/10.1021/ol702659a
Abstract
Oxidative coupling of three different arenes and a thiophene derivative with various arylboronic acids was achieved with a [RhCl(C2H4)2]2/P[p-(CF3)C6H4]3 catalyst system. Commercially available 2,2,6,6-tetramethylpiperidine-N-oxyl radical (TEMPO) was used as a stoichiometric oxidant. A 2-pyridyl group and an imine functional group served as ortho-directing groups to mediate the direct C-H arylation by a Rh complex. Moderate to excellent yields were obtained for the coupling reactions.Keywords
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