Calcitonin Secretion in Primary Hyperparathyroidism*

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Abstract
Plasma calcitonin (CT) was studied by RIA in 55patients with surgically proven primary hyperparathyroidism.Basal hormone measurements were performed in all patientsand provocative tests of CT secretion were performed in 7.Biochemical measurements were also made before and afterparathyroidectomy in 34 patients. Plasma CT was significantlyincreased above normal in the male but not the female group ofpatients with primary hyperparathyroidism. A similar sex differencein plasma CT was also seen during provocative testing. Incontrast to normal subjects, plasma CT was also significantlycorrelated to serum calcium concentration in the males but notthe females. Hormone concentrations returned to normal afterparathyroidectomy in the males and did not significantly changein the females. These studies demonstrate that some patientswith primary hyperparathyroidism, especially males, may havean increase, perhaps compensatory, in plasma CT. As withnormal females, females with primary hyperparathyroidismseem to have decreased CT reserve.

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