Penetration of cefotaxime and desacetylcefotaxime into skin blister fluid
- 1 September 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 10 (3) , 193-196
- https://doi.org/10.1093/jac/10.3.193
Abstract
Serum and suction skin blister fluid concentrations of cefotaxime (CT), and its metabolite, desacetylcefotaxime (DACT), were measured in four healthy volunteers during the first 10 h after an intravenous dose of 1·0 g CT. The blisters were produced by suction applied to the forearm skin prior to drug administration. The antibiotic concentrations were assayed by high-pressure liquid chromatography. The ratio of the areas under the concentration vs. time curves for blister fluid and serum (AUCblister/AUCserum) of DACT was nearly twice that of CT. This suggests a better penetration into skin blister fluid of the metabolite. The elimination half-life of CT was shorter in serum (0·85 h) than in blister fluid (3·0 h), whereas the difference was less for DACT (1·5 h vs. 3·8 h).Keywords
This publication has 1 reference indexed in Scilit:
- Assay of Cefotaxime by High-Pressure-Liquid ChromatographyChemotherapy, 1981