Investigation of the hemolytic effects of various organophosphoric acid triesters (OPEs) and their structure‐activity relationship

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Abstract
The hemolytic effects of various organophosphonc acid triesters (OPEs) were investigated and they showed strong hemolyic toxicity except triethyl phosphate and tris(chloroethyl)phosphate. 2‐Ethylhexyl diphenyl phosphate (EHDP) showed the strongest toxicity. By quantitative structure‐activity relationship (QSAR) study, one‐parameter regression equation to estimate hemolysis was not obtained. But, two‐parameter regression equations were obtained which were enought to estimate EC50 and EC20. The correlation coefficients with the two‐parameter regression equations were 0.939 for log(l/EC50) and 0.946 for log(l/EC20).