Regulation of Opioid Receptor Function by Chronic Agonist Exposure: Constitutive Activity and Desensitization
- 1 July 2001
- journal article
- review article
- Published by Elsevier in Molecular Pharmacology
- Vol. 60 (1) , 20-25
- https://doi.org/10.1124/mol.60.1.20
Abstract
Opium poppy extracts have been used for thousands of years to control pain, gut motility, and mood. However, chronic use of opiates can lead to tolerance, withdrawal, dependence, and addiction. Decades of study have established that the changes caused by sustained opioid receptor activation areThis publication has 52 references indexed in Scilit:
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