Circulating Prostate-Specific Antigen/CD14-Double-Positive Cells: a Biomarker Indicating Low Risk for Hematogeneous Metastasis of Prostate Cancer
Open Access
- 15 January 1997
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 89 (2) , 174
- https://doi.org/10.1093/jnci/89.2.174
Abstract
The presence of cells in the blood stream of prostate cancer patients that stain positively for both prostatespecific antigen (PSA) and for the monocyte marker CD14 seems to indicate a low risk of metastasis formation. This cellular biomarker might be helpful in the assessment of the prognosis for prostate cancer patients with organ- restricted disease. It could be used to define a subgroup of patients with a low risk of life-threatening bone metastasis, although these patients show evidence of circulating prostate cancer cells by flow cytometry ( 1 ) or PSAPCR2 ( 2 ).Keywords
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- Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reactionThe Lancet, 1991