Uptake of low density lipoprotein, albumin, and water by deendothelialized in vitro minipig aorta.

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Abstract
The purpose of this research was to study the effect of pressure on arterial hydration in vitro and the effect of pressure and flow (stirred reagent) on the in vitro transport of 125I-albumin and 125I-LDL into deendothelialized minipig aortas over a 24-hour period. It was found that the arterial hydration (fractional mass of water) was 0.740 +/- 0.0043 SEM for control tissue; after 24 hours this rose to 0.745 +/- 0.0038 for 0 mm Hg, 0.752 +/- 0.0046 for 100 mm Hg, and 0.755 +/- 0.0065 for 200 mm Hg. In the transport studies, the following effects were found. The reagent radioactivity concentration and composition did not change with pressure or stirring over the 24-hour period. For unpressurized tissue, the 24-hour normalized uptake [uptake (M mg cm-2) divided by reagent concentration (co mg cm-3)] of albumin was (4.86 +/- 0.43 cm) X 10(-3) from stirred and (5.46 +/- 0.36 cm) X 10(-3) from nonstirred reagent; that of LDL was (0.31 +/- 0.02 cm) X 10(-3) from stirred and (0.37 +/- 0.02 cm) X 10(-3) from non...

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