STEADY-STATE URINARY-EXCRETION OF THEOPHYLLINE AND ITS METABOLITES IN THE PRESENCE OF ERYTHROMYCIN

  • 1 January 1982
    • journal article
    • research article
    • Vol. 35  (2) , 341-344
Abstract
The effect of erythromycin on the quantitative pattern of urinary excretion of theophylline and its known metabolites at steady state in 8 human subjects was examined. The percent of dose excreted of the various compounds in the absence and presence of the antibiotic was as theophylline, 9.3 vs. 16.3, 1,3-dimethyluric acid, 51.9 vs. 59.6%, 3-methylxanthine, 11.9 vs. 13.0%; and 1-methyluric acid, 27.3 vs. 31.6%. Erythromycin did not influence the metabolism of theophylline under the experimental protocol employed.

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