The Influence of Insulin on the Raised Plasma Fibronectin Concentration in Human Obesity

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Abstract
Plasma concentrations of fibronectin, free insulin, C-peptide and plasma glucose were determined in 40 morbidly obese subjects and in 51 normal weight controls, matched for sex and age. All plasma concentrations were significantly elevated (p0.05). Plasma fibronectin was insignificantly correlated with body weight (obese r=0.21, controls r=0.15; p >0.05) and percentage overweight (obese r=0.27, controls r=0.04; p>0.05). The raised level of circulating insulin may in part explain the excess of plasma fibronectin of obese subjects.