EXPERIMENTS ON INTACT AND ADRENALECTOMIZED DOGS SUBJECTED TO SODIUM AND CHLORIDE DEPLETION BY INTRAPERITONEAL INJECTIONS OF GLUCOSE

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Abstract
The exptl. data show that conditions in adrenal insufficiency are strikingly similar to those occurring in the healthy, vigorous, adrenalectomized animal depleted of Na and Cl by intraperitoneal glucose. The 2 types of animals are physiologically comparable: they exhibit identical symptoms, similar changes in hemoconcentration, circulating fluid volume, arterial pressure and alterations in the distribution of body water; both lack ability to dilute the blood, i.e., redistribute the tissue fluids; and both react dramatically to injections of cortical hormone. The intact dog recovers spontaneously from Na and Cl depletion following intraperit. glucose injections; the animal lacking adrenals dies unless injected with cortical hormone or conc. salt solution.

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