CANCER-THERAPY WITH CHEMICALLY MODIFIED ENZYMES .2. THE THERAPEUTIC EFFECTIVENESS OF ARGINASE, AND ARGINASE MODIFIED BY THE COVALENT ATTACHMENT OF POLYETHYLENE-GLYCOL, ON THE TAPER LIVER-TUMOR AND THE L5178Y MURINE LEUKEMIA

  • 1 January 1984
    • journal article
    • research article
    • Vol. 7  (3) , 261-268
Abstract
Monomethoxypolyethylene glycol (PEG) was attached covalently to arginase. PEG-arginase was effective in prolonging the survival times of mice injected with the Taper liver tumor, whereas unmodified arginase was ineffective. PEG-arginase was more effective than arginase in the in vitro destruction of L5178Y mouse leukemia. Neither PEG-arginase nor arginase inhibited the in vivo growth of this tumor.

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