Fungal Transformation of the Antifungal Isoflavone Luteone
- 1 June 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 48 (6) , 1471-1477
- https://doi.org/10.1080/00021369.1984.10866338
Abstract
An antifungal isoflavone, luteone [5,7,2′,4′-tetrahydroxy-6-(3,3-dimethylallyl)isoflavone] is metabolised by cultures of Aspergillus flavus and Botrytis cinerea into 2″,3″-dihydro-3″-hydroxyluteone (AF-1), 2″,3″-dihydrodihydroxyluteone, a dihydrofuranoisoflavone (BC-1) and a dihydropyranoisoflavone. The structures of the metabolites were elucidated by physico-chemical and chemical procedures. The major metabolites, AF-1 and BC-1 are much less toxic than luteone against Cladosporium herbarum. The possible metabolic pathways are briefly discussed.This publication has 4 references indexed in Scilit:
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