ANTITUMOR-ACTIVITY OF SOME NEW PENTOPYRANOSYL-CHLOROETHYLNITROSOUREAS
- 1 January 1987
- journal article
- research article
- Vol. 181 (2) , 128-136
Abstract
Six N-(2-chloroethyl)-N-nitrosoureido derivatives of 4-deoxy-DL-pentopyranose have been synthesized and their antitumor activities were evaluated against melanoma MB16 in mice. The nitrosourea 38 was highly active in comparison with the clinically useful CCNU.This publication has 4 references indexed in Scilit:
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- A new class of nitrosoureas. III. Synthesis and antitumor activity of 3,3-disubstituted-1-(2-chloroethyl)-1-nitrosoureas having an arabinopyranosyl, xylopyranosyl or ribopyranosyl moiety.CHEMICAL & PHARMACEUTICAL BULLETIN, 1982
- INVIVO STUDY OF ACUTE HEMATOTOXICITY OF 3 NITROSOUREAS, CHLOROZOTOCIN, (CHLORO-2-ETHYL)-RIBOFURANOSYL-3-NITROSOUREA, AND (CHLORO-2-ETHYL)-1-RIBOPYRANOSYL-3-NITROSOUREA1980
- A structure-activity study of seven new water soluble nitrosoureasBiochemical Pharmacology, 1979