Conditioned media obtained from a human mastocytosis cell strain induce mast cells expressing chymase but not tryptase from human progenitors.
- 1 January 1997
- journal article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 113 (1) , 289-290
- https://doi.org/10.1159/000237576
Abstract
Human mast cells (MC) were derived from umbilical cord blood and bone marrow progenitors cultured in the presence of a conditioned medium from a human mastocytosis cell strain and recombinant human kit ligand (rhKL). KL induced MC of predominantly two immunophenotypes, MCT and MCTC. In contrast, the conditioned medium induced MC subtypes MCTC and a third subtype, MCC, positive for chymase but negative for tryptase. This study clearly demonstrates that a third type of MC, MCC, can be induced in vitro from normal human progenitors.Keywords
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