Prevalence of diabetes-specific autoantibodies in patients at risk for adult onset diabetes mellitus

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Abstract
To evaluate the potential of autoimmune markers in identifing patients with slowly progressive IDDM in the prediabetic state, we screened a population of 151 patients aged 37 — 70 years with impaired glucose tolerance (IGT) for the presence of islet cell antibodies (ICA), insulin autoantibodies (IAA), antibodies to glutamic acid decarboxylase (GADA), and antibodies to tyrosine phosphatase IA-2 (IA-2A). Autoantibodies were found in 5 (3.3%) patients with IGT suggesting the presence of an autoimmune-mediated Beta cell destruction. All of them were positive for high level ICA (>20 JDF-U) and 1 ICA positive subject had additional GADA (100 GADA-U). In contrast, none of the subjects had IA-2A or IAA. We here demonstrate a low prevalence of autoimmune diabetes among middle-aged subjects with IGT. ICA and GADA but not IA-2A or IAA may represent autoimmune markers for slowly progressive IDDM before the manifestation of the disease.

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