Pedigree and genotype errors in the Framingham Heart Study
Open Access
- 31 December 2003
- journal article
- Published by Springer Nature in BMC Genomic Data
- Vol. 4 (S1) , S41
- https://doi.org/10.1186/1471-2156-4-s1-s41
Abstract
The pedigree and genotype data from the Framingham Heart Study were examined for errors. Errors in 21 of 329 pedigrees were detected with the program PREST, and of these the errors in 16 pedigrees were resolved. Genotyping errors were then detected with SIMWALK2. Five Mendelian errors were found following the pedigree corrections. Double-recombinant errors were more common, with 142 being detected at mistyping probabilities of 0.25 or greater.Keywords
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