Palladium-catalyzed Cross-coupling of Phenylboronic Acid with Heterocyclic Aromatic Halides

1 January 1987

journal article
research article
Published by The Japan Institute of Heterocyclic Chemistry in HETEROCYCLES

Vol. 26 (10) , 2711-2716
https://doi.org/10.3987/r-1987-10-2711

Abstract

The coupling reaction of bromo- and iodopyridines 1 with phenylboronic acid (2a) by Pd(Ph3P)4 provides a convenient route to phenylpyridines, even when electrondonating or-withdrawing substituents are present. The method is also successful for the preparation of other phenylated N-containing heterocycles 5 as phenylquinolines and -pyrimidines.

Keywords

HETEROCYCLES

This publication has 1 reference indexed in Scilit:

Syntheses of 5-phenyl-2-pyridinamine, a possibly carcinogenic pyrolysis product of phenylalanine, and some of its putative metabolites
Carcinogenesis: Integrative Cancer Research, 1985