New route to N‐aryl and N‐heteroaryl derivatives of 4‐hydroxy‐3‐quinolinecarboxamides
- 1 September 1984
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 21 (5) , 1345-1353
- https://doi.org/10.1002/jhet.5570210520
Abstract
The synthesis of N‐aryl and N‐heteroaryl substituted 4‐hydroxy‐3‐quinolinecarboxamides 1 is described. The attack of dianions 12 of N‐aryl substituted acetamides on the C‐4 carbonyl of 4H‐3,1‐benzoxazin‐4‐ones 11 gave rise to ketoamides 13, which smoothly cyclised in the presence of bases to afford quinolinecarboxamides 1. By this method, a large number of 2‐substituted 4‐hydroxyquinolinecarboxamides can be prepared.This publication has 9 references indexed in Scilit:
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