An Orally Active Iron Chelator

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Abstract
Iron is essential for all organisms from bacteria to humans; but like excessive amounts of alcohol, which is so pleasant in moderation, a surfeit of iron is fatal. The lethal effects of iron overload can be immediate, as in an accidental or deliberate overdose of medicinal iron, or slow, as in congenital hemochromatosis and transfusional hemosiderosis. In the slowly developing conditions — the former due to hyperabsorption of iron in food and the latter to iatrogenic, as well as, in the case of thalassemia, hyperabsorptive factors — iron stores in the reticuloendothelial system are filled to the brim with nontoxic . . .