Identification of a Functional Allele of a Human Interferon-α Gene Previously Characterized as a Pseudogene
- 1 August 1989
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 9 (4) , 407-417
- https://doi.org/10.1089/jir.1989.9.407
Abstract
Three recombinant phage λL47 clones containing 4α interferon (IFN) genes have been isolated from a newly constructed human genomic library. Each gene is an allele of a previously described IFN gene, three being only minor variants. The fourth gene SMTIII.1A is a functional allele of the ψLeIF-L gene which previously has been described only as a pseudogene. Therefore, it appears likely that other variant alleles may remain to be described and that the IFN system may be able to tolerate some degeneracy as a consequence of the large number of members of the family.This publication has 30 references indexed in Scilit:
- Structural relationship of human interferon alpha genes and pseudogenesJournal of Molecular Biology, 1985
- A novel class of human type I interferonsNucleic Acids Research, 1985
- Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.Molecular and Cellular Biology, 1985
- Structure and properties of human interferon-α from Namalwa lymphoblastoid cellsBiochemical Journal, 1982
- Amino acid sequence of a human leukocyte interferon.Proceedings of the National Academy of Sciences, 1981
- Leukocyte and fibroblast interferon genes are located on human chromosome 9.Proceedings of the National Academy of Sciences, 1981
- The structure of eight distinct cloned human leukocyte interferon cDNAsNature, 1981
- Human leukocyte and fibroblast interferons are structurally relatedNature, 1980
- Amino Terminal Sequence of the Major Component of Human Lymphoblastoid InterferonScience, 1980
- Human leukocyte interferon: production, purification to homogeneity, and initial characterization.Proceedings of the National Academy of Sciences, 1979