Mercurial-Induced Transformation of Myosin Prevented by Adenosine Triphosphate and Pyrophosphate
- 17 September 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 149 (3690) , 1374-1375
- https://doi.org/10.1126/science.149.3690.1374
Abstract
Adenosine triphosphate and pyrophosphate prevent the loss of Ca÷÷-activated adenosine triphosphatase activity caused by high concentrations of mercurial sulfhydryl reagent. They concomitantly prevent the transformation of myosin into faster-sedimenting products. This is adduced as support for the hypothesis that the strategic sulfhydryl group is not binding adenosine triphosphate at the active site, but is initiating a conformational change upon its reaction with the mercurial reagent.This publication has 8 references indexed in Scilit:
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- Effects of adenosine triphosphate, potassium, and strophanthidin on the inhibition of a ouabain-sensitive adenosine triphosphatase by diisopropylfluorophosphateBiochimica et Biophysica Acta (BBA) - General Subjects, 1965
- The influence of cations on the reactivity of the sulfhydryl groups of actinBiochimica et Biophysica Acta, 1963
- Molecular changes in myosin caused by methylmercuric hydromeBiochimica et Biophysica Acta, 1961
- The binding of p-chloromercuribenzoate by myosinArchives of Biochemistry and Biophysics, 1961
- The Adenosine Triphosphatase Activity of Myosin B Treated with S-β-AminoethylisothiuroniumJournal of Biological Chemistry, 1960