Islet‐activating protein discriminates the antilipolytic mechanism of insulin from that of other antilipolytic compounds
- 5 September 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 161 (1) , 149-152
- https://doi.org/10.1016/0014-5793(83)80749-2
Abstract
In vivo administration of islet-activating protein to rats resulted in an increase in fat cell lipolysis in vitro, which was associated with almost complete resistance of adipocytes towards the antilipolytic effects of N 6-phenylisopropyladenosine, prostaglandin E2 and nicotinic acid. Concomitantly, the inhibitory effects of these compounds on adenylate cyclase activity in membranes were impaired. In contrast, the antilipolytic action of insulin was not only preserved, but even augmented in cells from rats treated with islet-activating protein. The data suggest that insulin exerts its antilipolytic effects via mechanisms which are different from those involved in the effects of prostaglandin E2, N 6-phenylisopropyladenosine and nicotinic acid.Keywords
This publication has 15 references indexed in Scilit:
- Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteinsNature, 1983
- Glycerol‐Releasing Activity of Histamine‐Sensitizing Factor of Bordetella pertussis for Rat Adipocytes In VitroMicrobiology and Immunology, 1982
- Microdetermination of glycerol using bacterial NADH-linked luciferaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1982
- Decreased sensitivity to α2 adrenergic amines, adenosine and prostaglandins in white fat cells from hamsters treated with pertussis vaccineFEBS Letters, 1981
- Regulation of adenylate cyclase activity in hamster adipocytesNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1980
- Inhibition of hamster fat cell adenylate cyclase by prostaglandin E1 and epinephrine: Requirement for GTP and sodium ionsFEBS Letters, 1979
- Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.Proceedings of the National Academy of Sciences, 1978
- Modulation of Adenylate Cyclase Activity in Liver and Fat Cell Membranes by InsulinScience, 1972
- Insulin action on the adenyl cyclase system: Antagonism to activation by lipolytic hormonesFEBS Letters, 1972
- An effect of insulin on adipose-tissue adenosine 3′:5′-cyclic monophosphate phosphodiesteraseBiochemical Journal, 1970