Isatin: Identity with the Purified Endogenous Monoamine Oxidase Inhibitor Tribulin
- 1 August 1988
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 51 (2) , 656-659
- https://doi.org/10.1111/j.1471-4159.1988.tb01089.x
Abstract
Purified tribulin, an endogenous monoamine oxidase (MAO) inhibitor, has been identified by direct probe insertion mass spectrometry as the indole-2,3-dione, isatin. A gas chromatographic-mass spectrometric assay for isatin has been developed and used to measure its relatively high concentrations in unpurified human urine, and in rat heart and brain. Isatin is a known compound with a broad range of biological activity; this is the first report of its presence in the animal body. Isatin is a potent inhibitor of MAO, particularly of MAO B (IC50, 3 μM), and also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM).Keywords
This publication has 12 references indexed in Scilit:
- Urinary Catecholamine Metabolite and Tribulin Output During Lactate InfusionThe British Journal of Psychiatry, 1988
- Variations in the monoamine oxidase-inhibitory activity (?tribulin??) in pig's urineJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1987
- Distribution of endogenous benzodiazepine receptor ligand-monoamine oxidase inhibitory activity (tribulin) in tissuesLife Sciences, 1986
- Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor bindingJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1986
- Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitorsNature, 1984
- New endogenous benzodiazepine receptor ligand in human urine: Identity with endogenous monoamine oxidase inhibitor?Life Sciences, 1983
- N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide and related N-tert-butyldimethylsilyl amides as protective silyl donorsThe Journal of Organic Chemistry, 1982
- Benzodiazepines reduce stress-augmented increase in rat urine monoamine oxidase inhibitorNature, 1981
- γ-Aminobutyric acid regulation of the benzodiazepine receptor: biochemical evidence for pharmacologically different effects of benzodiazepines and propyl β-carboline-3-carboxylateEuropean Journal of Pharmacology, 1981
- A monoamine oxidase inhibitor in human urineBiochemical Pharmacology, 1980