Mutational DNA base sequence changes in plasmid damaged at a specific region by ultraviolet light.
Open Access
- 1 January 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Radiation Research
- Vol. 27 (3) , 310-314
- https://doi.org/10.1269/jrr.27.310
Abstract
Mutational nucleotide sequence changes by ultraviolet light (UV) in the gene for Escherichia coli CAMP receptor protein (CRP) were analyzed. Transitions were most the frequent mutations and occurred at pyrimidine-pyrimidine sequences. Most transitions were GC to AT base changes at 3' cytosine of 5'-pyrimidinecytosine-3' sequences, supporting the concept that pyrimidine(6-4)pyrimidone, Pyr(6-4)Pyo, photoproduct is a principal pre-mutagenic lesion for transition mutations induced by UV. Transversion and frameshift mutations were also found.This publication has 5 references indexed in Scilit:
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