Monofluorophosphate Physiology: General Considerations

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Abstract
Ingested monofluorophosphate (MFP) is hydrolyzed by phosphatases mainly in the lumen and wall of the small intestine. MFP hydrolysis is insignificant in the saliva and the stomach and absorption is greatest in the small intestine, mainly or entirely as F ions. Liver tissue also rapidly hydrolyzes MFP, and MFP ions have not been found parenterally. The post-absorption physiology of MFP therefore appears to be identical with that of NaF, which is briefly summarized. However, the absorption peaks of F in blood and other body fluids and tissues occur earlier and are higher after NaF ingestion, unless F is bound by Ca ions in the digestive tract. Ca ions have a comparatively small effect on F absorption from MFP, and complex-bound Ca has practically no effect.

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