Toxic Effects of Chlorinated Hydrocarbon Insecticides

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Abstract
Electroencephalograms were obtained from a sample of 73 workmen who were continually exposed to chlorinated hydrocarbon insecticides (CHCI). Abnormal records were obtained in 16 cases (21.9%). The most severe changes were noted in the group exposed to CHCI for one to two years. Less severe changes were noted in groups with either shorter or longer exposure periods. The abnormal EEG patterns varied. Some of the records showed bitemporal sharp waves with shifting lateralization and, with low voltage, diffuse theta activity. Paroxysmal discharges composed of slow and sharp waves, most pronounced anteriorly, spike-wave complexes, and posteriorly located low-voltage rhythmic spikes were demonstrated in other records. None of those examined showed either abnormal neurological features or clinical convulsions. This study suggests high exposure of the workmen studied; however, it is not clear enough whether closure of the whole chemical plant or removal of persons from the high risk areas for long periods of time is warranted.

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