Phospholipin, a novel heterodimeric phospholipase A2 from Pandinus imperator scorpion venom
- 1 November 1999
- journal article
- Published by Wiley in FEBS Letters
- Vol. 460 (3) , 447-450
- https://doi.org/10.1016/s0014-5793(99)01392-7
Abstract
The primary structure of a phospholipase A2, with unique structural and functional characteristics, was determined. The large subunit has 108 amino acid residues, linked by a disulfide bridge to the small subunit, which contains 17 residues. Its gene was cloned from a cDNA library. The nucleotide sequence showed that the same RNA messenger encodes both subunits, separated only by a pentapeptide, that is processed during maturation.Keywords
This publication has 12 references indexed in Scilit:
- The Mechanism of Inhibition of Ryanodine Receptor Channels by Imperatoxin I, a Heterodimeric Protein from the Scorpion Pandinus imperatorJournal of Biological Chemistry, 1997
- The growing phospholipase A2 superfamily of signal transduction enzymesTrends in Biochemical Sciences, 1997
- Toxic peptides and genes encoding toxin γ of the Brazilian scorpions Tityus bahiensis and Tityus stigmurusBiochemical Journal, 1996
- Structure and Function Relationship of Crotoxin, a Heterodimeric Neurotoxic Phospholipase A2 from the Venom of a South-American RattlesnakePublished by Springer Nature ,1996
- Anti-inflammatory properties of a platelet-activating factor acetylhydrolaseNature, 1995
- Differences in primary structure among five phospholipases A2 from Heloderma suspectumEuropean Journal of Biochemistry, 1991
- Myotoxic components of snake venoms: Their biochemical and biological activitiesPharmacology & Therapeutics, 1990
- Biochemical characterization of the phospholipase A2 purified from the venom of the Mexican beaded lizard (Heloderma horridum horridum Wiegmann)Biochemistry, 1986
- beta-Bungarotoxin, a pre-synaptic toxin with enzymatic activity.Proceedings of the National Academy of Sciences, 1976
- A sensitive and specific plate test for the quantitation of phospholipasesAnalytical Biochemistry, 1972