A STUDY OF THE INDOL TUMOR OF CARREL IN REFERENCE TO GYE'S HYPOTHESIS REGARDING THE ORIGIN OF MALIGNANT GROWTHS*

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Abstract
Gye has not furnished satisfactory proof that the formation of tumors of the Rous sarcoma type is due to the activation of a per se inactive virus by a special factor present in the tumor tissue. The positive findings, reported by Gye, were due to the fact that the treatment of the tumor extract with chloroform, in the manner advocated by him, does not uniformly lead to the complete inactivation of the contained virus. The authors suggest that remaining and per se subinfective doses of the virus in such extracts may possibly be activated by some factor present in the so-called cultures, or that through the summation of sub-infective doses, present in both extracts and "cultures," tumor production may result. The writers failed to produce tumors by combining "embryonic tissue cultures" and chloroformed tumor extracts when the latter had been definitely inactivated.

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