TREATMENT OF PNEUMOCOCCAL MENINGITIS WITH LARGE DOSES OF PENICILLIN
- 1 May 1952
- journal article
- research article
- Published by American Medical Association (AMA) in A.M.A. Archives of Internal Medicine
- Vol. 89 (5) , 736-742
- https://doi.org/10.1001/archinte.1952.00240050050004
Abstract
THE RATIONALE for employing large doses of parenterally administered penicillin as a standard method of therapy for pneumococcal meningitis was first stated by Dowling and his group in 1949.1Their observations on a small series of 21 cases indicated that 1,000,000 units of aqueous crystalline penicillin administered intramuscularly every two hours was superior to all other previously described regimens of therapy for the disease.2It was their opinion that the use of intrathecally administered penicillin and/or the combination of a sulfonamide with penicillin was unnecessary, although in patients in coma on admission a single initial intrathecal dose of penicillin may be given. Dowling's recommended program for the therapy of pneumococcal meningitis has been followed in a small series of patients treated in this institution, and the results lend further proof to his original contention. METHODS The hospital courses of 20 consecutive patients2awith bacteriologically proved pneumococcal meningitisThis publication has 0 references indexed in Scilit: