Isolation and Characterization of a Novel Nucleoside from Human Cancer Urine
- 1 July 1986
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 5 (3) , 253-263
- https://doi.org/10.1080/07328318608069976
Abstract
A novel modified nucleoside, 5-carboxymethyluridine was isolated from 24 hour collection of urine from a lung carcinoma patient. The structure was assigned on the basis of UV, NMR and mass spectrometry, and confirmed by comparison of the spectral data and HPLC and paper chromatographic mobilities with those of the authentic sample. Possible origin and significance of this nucleoside is discussed.This publication has 13 references indexed in Scilit:
- Mass spectrometry of nucleic acid constituents. Trimethylsilyl derivatives of nucleosidesThe Journal of Organic Chemistry, 1982
- A comparative proton magnetic resonance conformational study of the tRNA "wobble" nucleosides 5-carboxymethyl-, 5-methoxycarbonylmethyl-, and 5-carbamoylmethyl-uridineCanadian Journal of Biochemistry, 1980
- Presence of the methylester of 5-carboxymethyl uridine in the wobble position of the anticodon of tRNAArgIII from brewer's yeastBiochimie, 1975
- The determination of 2′-O-methylnucleosides in RNAAnalytical Biochemistry, 1974
- Atypical Transfer RNA's And Their Origin In Neoplastic CellsPublished by Elsevier ,1972
- Differential labelling of the carboxymethyl and methyl substituents of 5-carboxymethyluridine methyl ester, a trace nucleoside constituent of yeast transfer RNABiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1970
- Synthesis of 5-carboxymethyluridine. Nucleoside from transfer ribonucleic acidBiochemistry, 1970
- Isolation and characterization of a novel nucleoside, N-[(9-β-D- ribofuranosyl-9H-Purin-6-YL) carbamoyl] threonine, from human urineLife Sciences, 1969
- Nucleosides in Human Urine I: Isolation and Identification of N2-Dimethylguanosine, 1-Methylinosine, and N2-Methylguanosine from Normal Human UrineJournal of Pharmaceutical Sciences, 1969
- 5-Carboxymethyluridine, a novel nucleoside derived from yeast and wheat embryo transfer ribonucleatesBiochemistry, 1968