Propagation of Signals of Finite Concentration in Gas Chromatography. I. The Quasi-Ideal Model

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Abstract
A general system of partial differential equations describing the propagation of signals of finite concentrations in a chromatographic column is derived. These equations are related to the mass-balance equations for the solutes and the carrier gas. The model used assumes that there is no temperature or pressure variation at any point in the column when the signal is eluted, and that the equilibrium between stationary and mobile phases is instantaneous. It is shown that this model, which leads to a tractable set of equations, is generally valid. The solution of this system of equations gives new insight into the phenomena which are responsible for the peak deformations and broadening in preparative scale chromatography.