Oral Contraceptives, Lanosterol, and Platelet Hyperactivity in Rat
- 7 November 1980
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 210 (4470) , 642-644
- https://doi.org/10.1126/science.7433990
Abstract
Lanosterol, a cholesterol precursor that increases considerably in the platelets of rats treated with oral contraceptives, was incubated with either platelet-rich plasma or washed platelet suspension. After 2 minutes there was a remarkable dose-related increase in platelet activity. This platelet hyperactivity was measured by clotting time and platelet aggregation could not be reproduced by cholesterol or ethinylestradiol.This publication has 8 references indexed in Scilit:
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